"A.N.T. Farm" revolves around Chyna Parks, an 11-year-old musical prodigy who attends a high school as part of the prestigious A.N.T. (Advanced Natural Talents) program. She, along with her fellow A.N.T.s, Olive Doyle and Fletcher Quimby, must find their place and make the most of their high school experience.
When Chyna arrives at her San Francisco high school, she befriends Olive, an 11-year-old A.N.T. who has a photographic memory and is able to recall everything she has ever read, seen or heard; and Fletcher, an artistic genius with a knack for using his creations for playful hijinks. Chyna takes reign to convince Olive and Fletcher that they can fit in, despite their age, as long as they take advantage of every opportunity that comes their way. She encourages them to try out for things that they are interested in, including the cheerleading squad and school musical, and she even drags them to a high school house party.
Meanwhile, Lexi Reed, a popular high schooler who has grown accustomed to being the best at everything and resents Chyna's natural-born talents, and Chyna's older brother Cameron Parks, who often overcompensates in mischievous ways in order to escape his sister's shadow, don't welcome the A.N.T.s warmly to their high school. Lexi doesn't appreciate her newfound competition for the lead in the school play and tries to sabotage Chyna's chances to outshine her. Similarly, Cameron tries to act as if he does not know Chyna.
